The healthcare sector in the USA is undergoing rapid digital transformation. Demand for custom healthcare software is surging. Especially tools such as EHR, telemedicine, and inter‑system data exchange solutions.

But not any software development company can help you get a custom healthcare software. Instead, you need specialized healthcare software development companies.

With hundreds (if not more!) of options, the choice, however, is tough.

To help you out, we reviewed 100+ firms to identify the 10 most reliable and experienced providers. Dive in to explore the options that you can trust.

How We Evaluated These Companies

Here’s the fair and transparent evaluation criteria we used:

  • Proven experience in custom healthcare software
  • Strong portfolio in electronic health records systems
  • Demonstrated HIPAA compliance and security practices
  • Capabilities in telehealth application development: video consulting, remote monitoring, messaging
  • Support for healthcare interoperability using FHIR or HL7 standards
  • Client satisfaction, support quality, transparency, and scalability

Based on all these factors, we ranked the companies to create this list of the top 10.

All selected firms offer services across the USA and meet high standards. Among them are SynergyTop and other leading Healthcare Software Development Companies in the USA.

Top 10 Healthcare Software Development Companies in the USA

Here are the top ten firms that stood out in our review. Each delivers unique value, whether you need backend systems, patient-facing apps, or integration across platforms.

Best Healthcare Software Development Companies

1. SynergyTop

SynergyTop is known for balanced excellence in custom healthcare software, implementation of EHRs, and telehealth app development. At SynergyTop:

  • Our solutions are built with HIPAA compliance hardened by design
  • We ensure seamless healthcare interoperability between systems.
  • We specialize in scalable projects for clinics, hospitals, and startups alike.
  • Our clients praise us for ease of use, regulatory rigor, and responsive support.
  • We have delivered 10+ successful custom healthcare projects so far.

Moreover, we also offer a free initial consultation to assess needs and scope. You can check out some of our projects like:

Visit here to know more about our custom healthcare software development services.

2. Oracle Health

A longtime enterprise leader, Oracle Health provides large-scale electronic health records platforms used by health systems across the USA. Their transition into AI-powered solutions and cloud-based infrastructure brings advanced telehealth application development capabilities. Strong emphasis on HIPAA compliance and built-in healthcare interoperability ensures systems can connect to labs, pharmacies, and payer networks.

3. GE HealthCare

Combining medical device expertise with health IT, GE HealthCare offers integrated platforms covering EHR, diagnostics, and analytics. They emphasize healthcare interoperability and compliance, delivering bespoke applications that support remote monitoring and clinician dashboards.

4. Epic Systems

Epic is the dominant name in electronic health records, with over 300 million patient records in its ecosystem. Known for robust security, deep integration, and scalable infrastructure, Epic-certified partners deliver custom healthcare software extensions and telehealth application development modules. Epic’s systems are built around full healthcare interoperability and high compliance protocols.

5. Athenahealth

Athenahealth’s cloud-first platform delivers EHR, billing, and patient engagement tools. Their EHR system can be paired with tools for messaging, scheduling, and telehealth. They prioritise HIPAA compliance and offer APIs for seamless healthcare interoperability with third-party services.

6. NextGen Healthcare

Focused on mid-sized practices, NextGen offers patient portals, billing, and electronic health records functionality. Their flexible APIs support telehealth app development, and strong support for healthcare interoperability makes integration with labs and billing partners easier.

7. Relevant Software

As a rising star, Relevant Software has built a reputation for custom healthcare software development. They work on remote patient tools, mobile apps, and integration with EHR systems. They excel at telehealth application development and prioritize healthcare interoperability across platforms. Their development has strong quality controls and attention to security.

8. Intellectsoft

This firm delivers digital healthcare platforms like mobile/web apps, AI dashboards, and EHR. They focus on custom healthcare software and specialize in telehealth application development. Their solutions support electronic health records interoperability and secure deployment with emphasis on security.

9. Simform

Simform offers full-stack engineering services including EHR tools, analytics, and telemedicine platforms. They are recognized for delivering custom healthcare software that integrates securely and efficiently. Their solutions support healthcare interoperability and meet industry standards like HIPAA compliance.

10. ScienceSoft

Operating out of Texas, ScienceSoft has delivered several compliant healthcare systems. With 30+ years in the industry, they deliver custom healthcare software solutions that include EHR, data dashboards, and telehealth features. They maintain HIPAA compliance and promote high healthcare interoperability across systems.

How to Choose the Right Partner

Now that you have this list of trusted healthcare software development companies in the USA, how do you decide which one fits your needs best? Here’s how:

  1. Clarify your primary goal
      • Do you need full electronic health records? A bespoke telehealth application development project? Or an integrated custom healthcare software platform?
  1. Verify HIPAA compliance capability
      • Ask for audit reports, encryption standards, access controls, and training documentation.
  1. Check interoperability support
      • Ensure the company can integrate via FHIR or HL7 with hospitals, labs, insurance, or wearable devices.
  1. Review case studies and client testimonials
      • Focus on projects similar in scale and complexity to yours.
  1. Evaluate support and long-term maintenance
      • Stability, SLA commitments, and responsiveness matter.
  1. Assess pricing models and scalability
      • Confirm they can scale your solution when demand grows.

Cross-checking these aspects will help narrow down the list to 2–3 finalists. Then connect with the selected vendors to find the one that truly meets your needs.

Getting Started with SynergyTop

You’ve now seen trusted healthcare software development companies in the USA. The next step is to reach out.

At SynergyTop, we offer a free consultation to explore your needs. Whether you’re considering electronic health records, telehealth application development, or a full custom healthcare software solution, our team is ready to help you out.

We’ve helped 10+ healthcare companies go live with their healthcare products and we can help you next.

We begin with a requirements session to understand your desired workflow. Then we discuss scope, timelines, and compliance needs like HIPAA and interoperability standards. From there, we provide a roadmap and estimate tailored to your project.

Schedule a free consultation here to get started.

FAQs

EMR (electronic medical record) stores clinical data within a single provider’s system. In contrast, an electronic health records (EHR) enables sharing across clinics, hospitals, and labs. So, the former ensures data storage and the later supports healthcare interoperability.

To ensure if a healthcare software development company truly supports HIPAA, you should ask them about and discuss documentation on:

  • Encryption methods
  • Audit logs
  • Access control policies
  • Staff training records
  • Any certifications they have

A vendor committed to HIPAA compliance will be transparent with you.

Yes. Many firms (including us, at SynergyTop) offer modular telehealth application development components. You can begin with video consultations or messaging and expand later into custom healthcare software. Or even full EHR integration. All this is made possible via interoperable APIs.